Neurotoxicity of the Organochlorine Insecticide Heptachlor to Murine Striatal Dopaminergic Pathways
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چکیده
منابع مشابه
Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways.
Changes in biochemical status of nerve terminals in the corpus striatum, one of the primary brain regions affected in Parkinson's disease, were studied in groups of C57BL/6 mice treated by ip injection three times over a 2-week period with 3--100 mg/kg heptachlor. On average, the maximal rate of striatal dopamine uptake increased > 2-fold in mice treated at doses of 6 mg/kg heptachlor and 1.7-f...
متن کاملMetabolism of organochlorine pesticide heptachlor and its metabolite heptachlor epoxide by white rot fungi, belonging to genus Phlebia.
White rot fungi of the genus Phlebia have demonstrated a high capacity to degrade organic pollutants, including polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls. In this study, we evaluated the ability of 18 white rot fungi species of genus Phlebia to degrade heptachlor and heptachlor epoxide, and described the metabolic pathways by selected white rot fungi. Phlebia tremellosa, P...
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chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولHeptachlor and Heptachlor Epoxide
9. REFERENCES ACGIH. 1986. Documentation of the threshold limit valves and biological exposure indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 296. ACGIH. 2004. Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH: American Conference of Governmental Industrial Hygienists. Adeshina F, Todd ...
متن کاملReduction of striatal dopaminergic neurotransmission elevates striatal proenkephalin mRNA.
Dopamine-containing neurons have been shown to make direct contact with enkephalin-like immunoreactive neurons in the striatum of rat brain (Kubota et al., 1986). Chronic blockade of dopaminergic neurotransmission with the neuroleptic drug haloperidol has been reported to increase the striatal concentration of methionineenkephalin and proenkephalin m R N A (ENK mRNA) (Tang et al., 1983). We inv...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2001
ISSN: 1096-0929
DOI: 10.1093/toxsci/61.1.100